Anti-DCLRE1C (aa 306-692) polyclonal antibody-null-抗体-生物在线
北京安必奇生物科技有限公司
Anti-DCLRE1C (aa 306-692) polyclonal antibody

Anti-DCLRE1C (aa 306-692) polyclonal antibody

商家询价

产品名称: Anti-DCLRE1C (aa 306-692) polyclonal antibody

英文名称: Anti-DCLRE1C polyclonal antibody

产品编号: DPABH-03549

产品价格: null

产品产地: USA

品牌商标: Creative Diagnostics

更新时间: null

使用范围: WB, IHC-P

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Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5-3 exonuclease activity in isolation and acquires endonucleolytic activity on 5 and 3 hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. *   http://www.creative-diagnostics.com/Anti-DCLRE1C-PAb-200796-147.htm